Fluphenazine came into use in 1959.  The injectable form is on the World Health Organization's List of Essential Medicines , the most effective and safe medicines needed in a health system .  It is available as a generic medication .  In the United States the tablets costs between and USD per day for a typical dose.  The wholesale cost in the developing world of the long acting form is between and USD per injection as of 2014.  It was discontinued in Australia around mid 2017. 
It should not be used concomitantly with medications known to prolong the QTc interval (. 5-HT3 antagonists , tricyclic antidepressants , citalopram , etc.) as this may lead to an increased risk of QTc interval prolongation.   Neither should it be given concurrently with lithium (medication) as it may increase the risk of lithium toxicity and neuroleptic malignant syndrome .    It should not be given concurrently with other antipsychotics due to the potential for this to increase the risk of side effects, especially neurological side effects such as neuroleptic malignant syndrome .    It should be avoided in patients on CNS depressants such as opioids, alcohol and barbiturates.