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Alkaline phosphatase, hemoglobin and hematocrit, and creatinine may vary depending on the patient's current sex hormone configuration. Several factors contribute to these differences, bone mass, muscle mass, number of myocytes, presence or lack of menstruation, and erythropoetic effect of testosterone. Many transgender men do not menstruate, and those with male-range testosterone levels will experience an erythropoetic effect. As such an amenorrheic transgender man taking testosterone, registered as female and with hemoglobin/hematocrit in the range between the male and female lower limits of normal, may be considered to have anemia, even though the lab report may not indicate so. Conversely, the lack of menstruation, and presence of exogenous testosterone make it reasonable to use the male-range upper limit of normal for hemoglobin/hematocrit. Using the male-range upper limit of normal for alkaline phosphatase and creatinine may also be appropriate for transgender men due to increased bone and muscle mass, respectively. In these cases the provider should reference the male normal ranges for their lab.
Prostate cancer is the most common cancer and the second leading cause of cancer-related deaths among men in the United States.  The prostate is a walnut-sized gland behind the base of a man’s penis and below the urinary bladder. Its function is to make seminal fluid, which is the liquid in semen that protects, supports, and helps transport sperm.  Once you understand the risk factors of prostate cancer, you can undergo tests, implement lifestyle changes, or take medications or supplements to help reduce your risk of prostate cancer.