Who should not take Testosterone Replacement Therapy?
TRT is not appropriate if you have prostate, testicular, breast or some other types of cancer. You should not undergo TRT if you are currently receiving chemo or radiation therapy or have had surgery within the past six weeks. Some medical conditions may prevent you from taking TRT, including swelling, shortness of breath, sleep apnea, heart disease, kidney disease, liver disease or cirrhosis, alcoholism, untreated asthma, untreated COPD or emphysema, untreated diabetes, adrenal gland disorder, prostate enlargement, untreated thyroid disorder. Many professional, high school or college sports prohibit the use of testosterone injections.
In males, LH triggers the production of testosterone by Leydig cells in the testes, which, of course, acts as an endocrine hormone and is essential for the production of sperm. Because it is part of the hypothalamic-pituitary-gonadal axis, its levels are regulated by stimulation and inhibition by GnRH and testosterone (T). Thus, when T levels are low, the hypothalamus is stimulated to increase production of GnRH. This increase in GnRH in turn stimulates LH production. Thus, high LH levels can be an indicator of low T. (Similarly, high FSH levels can also be an indicator of low T.)