A 2007 study investigated the interaction between bisphenol A's and estrogen-related receptor γ (ERR-γ). This orphan receptor (endogenous ligand unknown) behaves as a constitutive activator of transcription. BPA seems to bind strongly to ERR-γ ( dissociation constant = nM), but only weakly to the ER.  BPA binding to ERR-γ preserves its basal constitutive activity.  It can also protect it from deactivation from the SERM 4-hydroxytamoxifen (afimoxifene).  This may be the mechanism by which BPA acts as a xenoestrogen .  Different expression of ERR-γ in different parts of the body may account for variations in bisphenol A effects. For instance, ERR-γ has been found in high concentration in the placenta , explaining reports of high bisphenol accumulation in this tissue.  BPA has also been found to act as an agonist of the GPER (GPR30). 
Cardiovascular disease: This medication often affects blood pressure and can contribute to symptoms of heart disease. If you have high blood pressure, heart disease such as heart failure, angina, or a previous heart attack, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If you are taking blood pressure pills to control blood pressure, it is important to continue taking them regularly while you are on epoetin alfa. Your doctor will monitor your hemoglobin (the protein in red blood cells that carry oxygen) until an appropriate dose of epoetin alfa has been determined.