Piracetam improves the functioning of the (ACh) transmitters and receptors. Acetylcholine , abbreviated as (ACh), is implicated in memory processes and development. Choline sources, like Alpha GPC and choline bitartrate, increase the production of Acetylcholine. Piracetam, belonging to the racetam class of nootropics, stimulates, increases, and improves the activities of these ACh receptors. Not only is ACh implicated in memory processes, the chemical compound is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms, including humans.
Simvastatin 20-40 mg/day modestly potentiated the effect of coumarin anticoagulants: the prothrombin time , reported as International Normalized Ratio (INR), increased from a baseline of to and from to in a normal volunteer study and in a hypercholesterolemic patient study, respectively. With other statins, clinically evident bleeding and/or increased prothrombin time has been reported in a few patients taking coumarin anticoagulants concomitantly. In such patients, prothrombin time should be determined before starting VYTORIN and frequently enough during early therapy to ensure that no significant alteration of prothrombin time occurs. Once a stable prothrombin time has been documented, prothrombin times can be monitored at the intervals usually recommended for patients on coumarin anticoagulants. If the dose of VYTORIN is changed or discontinued, the same procedure should be repeated. Simvastatin therapy has not been associated with bleeding or with changes in prothrombin time in patients not taking anticoagulants.
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