DEPO - Testosterone (testosterone cypionate injection) is an androgen indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone including, 1) Primary hypogonadism ( congenital or acquired ) - testicular failure due to cryptorchidism , bilateral torsion, orchitis , vanishing testis syndrome, or orchidectomy; and 2) Hypogonadotropic hypogonadism (congenital or acquired) - gonadotropin or LHRH deficiency, or pituitary -hypothalamic injury from tumors, trauma , or radiation . Common side effects of DEPO -Testosterone include:
We have studied the effect of a pharmacological dose of testosterone enanthate (3 --1 for 12 wk) on muscle mass and total-body potassium and on whole-body and muscle protein synthesis in normal male subjects. Muscle mass estimated by creatinine excretion increased in all nine subjects (20% mean increase, P less than ); total body potassium mass estimated by 40K counting increased in all subjects (12% mean increase, P less than ). In four subjects, a primed continuous infusion protocol with L-[1-13C]leucine was used to determine whole-body leucine flux and oxidation. Whole-body protein synthesis was estimated from nonoxidative flux. Muscle protein synthesis rate was determined by measuring [13C]leucine incorporation into muscle samples obtained by needle biopsy. Testosterone increased muscle protein synthesis in all subjects (27% mean increase, P less than ). Leucine oxidation decreased slightly (17% mean decrease, P less than ), but whole-body protein synthesis did not change significantly. Muscle morphometry showed no significant increase in muscle fiber diameter. These studies suggest that testosterone increases muscle mass by increasing muscle protein synthesis.
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