Testosterone pain

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Simply order a morning serum testosterone level. Laboratories now report a patient’s serum concentration as well as normal ranges for males and females. Units of measure may vary between laboratories. The total serum testosterone concentration has protein-bound and unbound components. 13-15 The free, bioavailable, or unbound component is generally believed to be the fraction most involved with libido and sexual function. We believe, however, that the total serum testosterone levels may be a more critical evaluation for pain management purposes, since protein-bound testosterone may be necessary to either enter some body compartments such as in the CNS, spinal cord, or pain site to perform its necessary functions. Consequently, pain practitioners should consider low levels of either total serum testosterone or free unbound testosterone to indicate a deficiency that requires replacement.

At this time there is a raging debate among some endocrinologists and urologists as to the meaning of serum free and total testosterone and sex hormone binding globulin. The issue stems from the fact that most (over 80%) of serum testosterone, is bound to serum proteins including sex hormone binding globulin. Some experts believe that only about 1% of serum testosterone is “active,” due to the protein/globulin binding nature of testosterone. They even argue that the remaining protein-bound testosterone is irrelevant and apparently some sort of biologic waste product. At this time, it is recommended that pain practitioners let the testosterone debates rage on and simply use laboratory-reported serum levels of free or total testosterone in combination with clinical symptoms as the reason to initiate a low dose clinical trial.

Common (1% to 10%): Sinusitis, nasopharyngitis, upper respiratory tract infection, bronchitis
Uncommon (% to 1%): Cough, dyspnea, snoring, dysphonia
Rare (less than %): Pulmonary microembolism (POME) (cough, dyspnea, malaise, hyperhidrosis, chest pain, dizziness, paresthesia, or syncope) caused by oily solutions
Frequency not reported: Sleep apnea
Postmarketing reports: Chest pain, asthma, chronic obstructive pulmonary disease, hyperventilation, obstructive airway disorder, pharyngeal edema, pharyngolaryngeal pain, pulmonary embolism, respiratory distress, rhinitis, sleep apnea syndrome [ Ref ]

Testosterone pain

testosterone pain

Common (1% to 10%): Sinusitis, nasopharyngitis, upper respiratory tract infection, bronchitis
Uncommon (% to 1%): Cough, dyspnea, snoring, dysphonia
Rare (less than %): Pulmonary microembolism (POME) (cough, dyspnea, malaise, hyperhidrosis, chest pain, dizziness, paresthesia, or syncope) caused by oily solutions
Frequency not reported: Sleep apnea
Postmarketing reports: Chest pain, asthma, chronic obstructive pulmonary disease, hyperventilation, obstructive airway disorder, pharyngeal edema, pharyngolaryngeal pain, pulmonary embolism, respiratory distress, rhinitis, sleep apnea syndrome [ Ref ]

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